The Nigeria national action plan on antimicrobial resistance provides a comprehensive framework to combat rising drug resistance through coordinated strategies across human, animal, and environmental health sectors. It emphasizes strengthening surveillance systems, promoting rational use of antibiotics in healthcare and agriculture, and enforcing regulatory controls over drug distribution. Public awareness campaigns and capacity-building for healthcare professionals and veterinarians are central to its success. Additionally, the plan advocates investment in research to better understand resistance patterns and develop new treatment options. Effective implementation of the Nigeria national action plan on antimicrobial resistance is essential to safeguard public health, preserve antibiotics, and prevent future outbreaks of untreatable infections.