The Eagles will look to get back into the win column on Sunday afternoon when they go on the road to play the Colts at Lucas Oil Stadium (1 p.m. ET, CBS). Philadelphia suffered its first lo s this season last Monday against the Commanders, while the Colts snapped their three-game losing streak with a win over the Raiders in Jeff Saturday's head coaching debut.Philadelphia got punched in the mouth by Washington, who executed its gameplan on both sides of the ball. The Commanders won the time of po se sion battle (40:24-19:36) and destroyed the Eagles' defense on third down, converting 12-of-21 third downs. The Eagles' defense also struggled to stop the run for the second-straight week, allowing the Commanders to run for 152 yards. It's not a good sign with Jonathan Taylor next on the schedule. As for the offense, Jalen Hurts completed 17-of-26 pa ses for 175 yards, two touchdowns, and an interception while also adding a rushing TD. One of Hurts' TD pa ses went to tight end Dallas Goedert, who will be out for some time due to a shoulder injury.Meanwhile, the Colts played inspired football under first-time head coach Jeff Saturday, defeating the Raiders 25-20 last week. Matt Ryan was back in the starting lineup after being benched for Sam Ehlinger, and he played reasonably well, throwing for 222 yards and a touchdown while also adding a rushing touchdown. Taylor also made an impact in the win on Sunday, posting 147 rushing yards and a touchdown on 22 carries. It was just his second 100-yard game and second TD of the season.WEEK 11 NFL PICKS: | Below, we'll give you all the information you need before placing a wager on Eagles-Colts, including the updated odds from Sports Interaction, tips, and our prediction for this Week 11 matchup.Spread: Eagles-6.5Over/Under: 45Moneyline: Eagles-295, Colts +243The Eagles opened up as nine-point favorites on Monday at various sportsbooks, but the number Bryan Baker Jersey came down after their first lo s. Philadelphia has not covered the spread in back-to-back games against the Texans and Commanders. The total is set at 45 points, which makes sense considering the Eagles have one of the top-scoring offenses in the NFL (27.3 points per game) and the Colts' defense has given up 20.3 points per game.The Colts lead the all-time series over the Eagles with a record of 10-9. However, the Eagles have won the past three matchups, dating back to the 2010 season. The last time these two teams played each other was in Week 3 in 2018 when the Eagles defeated the Colts 20-16 at Lincoln Financial Field. Doug Pederson and Frank Reich were the head coaches in this game, and the starting quarterbacks were Carson Wentz and Andrew Luck.-- The Colts are 3-2 against the spread and 3-2 straight up as an underdog this season, .-- Eagles head coach Nick Sirianni is 14-1 straight up as a favorite in his head coaching career, per BetQL.-- The Eagles are 5-4 ATS as the favorite but 1-3 ATS on the road this season.Can the Eagles' run defense slow down Jonathan Taylor?Over the past two weeks, teams have figured out that you can run on the Eagles' defense and find succe s no matter the down. The Commanders took advantage, rushing for 152 yards and controlling the time of po se sion. Washington was able to convert multiple third-and-short situations thanks to their succe s on the ground. Now, the Eagles have to go up against one of the best young running backs in the NFL, Jonathan Taylor.Taylor has struggled this season due to injury but finally got back on track last week against the Raiders. The former Wisconsin standout ran for 147 yards and a touchdown on 22 carries. If Taylor can be succe sful on first and second down, it could be a long day for the Eagles' defense.What will the Eagles do without Dallas Goedert?The Eagles suffered a tough lo s on Monday night when Goedert exited because of a shoulder injury. Goedert filled in nicely as the team's No. 2 receiving option behind star wide receiver A.J. Brown this season, recording 43 receptions (53 targets) with 544 yards and three touchdowns.Without the standout tight end in the lineup, Eagles QB Jalen Hurts will have to lean more on the duo of Jack Stoll and rookie Grant Calcaterra at tight end. They are not ideal options for the Eagles, as Goedert was the complete package. However, all four pa s-catchers bring something different to the table, which could help this offense on Sunday afternoon.Can Matt Ryan play clean football?If the Colts want to pull off another huge win on Sunday, they will need Ryan to limit mistakes against an opportunistic Eagles' defense. Philadelphia does not blitz offense but has still found a way to lead the NFL in takeaways (19). Before returning to the starting lineup last week, Ryan was a turnover machine, throwing nine interceptions in seven games. Colts' fans hope Ryan's turnover i sues are behind because he will be going up against an Eagles' secondary that has two solid cornerbacks (Darius Slay and James Bradberry) and a ball-hawking safety in C.J. Gardner-Johnson, who leads the league with six interceptions.15.7.This is how many points per game the Colts have scored on offense this season. Last week's 25-20 over the Raiders was the first time since Week 6 against the Jaguars (34 points) that the Colts scored at least 20 points. If Indianapolis wants to win at home on Sunday, they must be better inside the 20, where they have the third-worst red-zone percentage (44.4) and third-down conversion rate (37.3 percent).After being outplayed and outcoached on Monday night, the Eagles get their act together and pick up the road win thanks to a strong second-half performance on Sunday. The Colts will make life hard for the Eagles' defense, especially with Taylor on the ground. However, Philly's defense will come away with a key turnover, and the offense will get back to its ground-and-pound mentality to secure the win.PREDICTION: Eagles 27, Colts 17. The Eagles will cover (-6.5), and the total will go UNDER (45). Mark Belanger Jersey